Epub⋙: Computational Modelling of the Human Islet Amyloid Polypeptide (Springer Theses) by Katrine Kirkeby Skeby

Computational Modelling of the Human Islet Amyloid Polypeptide (Springer Theses) by Katrine Kirkeby Skeby

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The thesis presents research on human islet amyloid polypeptide (hIAPP) using computational modeling, offering readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Several studies in the thesis answer difficult questions, which promote future research into the properties of amyloid proteins. Understanding the experimental literature has enabled the results to be critically assessed and compared to both the literature and the experiments performed by other researchers, which further elevates the quality of the research.

 

hIAPP forms cytotoxic plaques in the pancreas, and is associated with the development of type 2 Diabetes Mellitus, one of the amyloid family of diseases, which are characterized by deposits of a particular peptide in the body. The results presented here represent a significant contribution to amyloid research, especially with regard to the origin of cytotoxicity and to developing technologies for early detection. Amyloid proteins are highly complex, and this research provides unparalleled insights, revealing in detail the molecular mechanisms behind hIAPP behavior.

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Epub⋙: Evolutionary Optimisation of Façade Design: A New Approach for the Design of Building Envelopes (Green Energy and Technology) by Giovanni Zemella, Andrea Faraguna

Evolutionary Optimisation of Façade Design: A New Approach for the Design of Building Envelopes (Green Energy and Technology) by Giovanni Zemella, Andrea Faraguna

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Optimization techniques offer immense potential for the improvement of performance-driven design, since they allow the adoption of an holistic approach. This can lead to great advantages: optimal design solutions can be properly identified only if all criteria are considered at the same time, rather than separately. There are two barriers which obstruct optimization from being applied to building design: a technological barrier (applying the algorithms is not easy and can be quite time-consuming) and a cultural one (architects and engineers are required to change their perspectives as the design process has to be handled in a new way). This book explores these barriers from the perspective of both engineers and architects, and proposes a change in the attitudes of these two “actors”: an engineer and an architect develop a dialog which helps them understand each other’s perspective; in this way they find how they must both make a step forward.

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Epub⋙: Steroid Dimers: Chemistry and Applications in Drug Design and Delivery by Satyajit Sarker, Lutfun Nahar

Steroid Dimers: Chemistry and Applications in Drug Design and Delivery by Satyajit Sarker, Lutfun Nahar

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Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create  “molecular umbrellas” for drug delivery.

Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include:

• introduction to steroid dimers
• synthesis and chemistry of noncyclic and cyclic steroid dimers
• naturally occurring steroid dimers – cephalostatins, ritterazines and crellastatins
• biological and pharmacological functions of steroid dimers and their application in drug design and discovery
• steroid dimers as “molecular umbrellas” for drug delivery

Steroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and  medicinal chemistry, and drug design, discovery and delivery.

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Epub⋙: The Origin and Evolution of Mammals by T. S. Kemp

The Origin and Evolution of Mammals by T. S. Kemp

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Mammals are the dominant large animals of today, occurring in virtually every environment. This book is an account of the remarkable fossil records that document their origin since the extinction of the dinosaurs. Tracing their evolution over the last 35 million years. For the first time presented in one single volume Kemp unveils the exciting DNA sequence evidence which coupled with fossil evidence challenges current thinking on the relationships amongst mammal and their inferred history.



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Epub⋙: The Billionaires' Brides Bundle: The Italian Prince's Pregnant Bride/The Greek Prince's Chosen Wife/The Spanish Prince's Virgin Bride by Sandra Marton

The Billionaires' Brides Bundle: The Italian Prince's Pregnant Bride/The Greek Prince's Chosen Wife/The Spanish Prince's Virgin Bride by Sandra Marton

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Take three incredibly wealthy European princes and match them with three beautiful, spirited women. Add large helpings of intense emotion and passionate attraction. Result: three unexpected pregnancies--and three possible princesses, if those princes have their way.

Get Sandra Marton's Billionaires' Brides trilogy in one download! Bundle includes The Italian Prince's Pregnant Bride, The Greek Prince's Chosen Wife, and The Spanish Prince's Virgin Bride.

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Epub⋙: All You Need Is Kill (Graphic Novel) by Hiroshi Sakurazaka

All You Need Is Kill (Graphic Novel) by Hiroshi Sakurazaka

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When the alien Mimics invade, Keiji Kiriya is just one of many recruits shoved into a suit of battle armor called a Jacket and sent out to kill. Keiji dies on the battlefield, only to be reborn each morning to fight and die again and again. On his 158th iteration, he gets a message from a mysterious ally--the female soldier known as the Full Metal Bitch. Is she the key to Keiji's escape or his final death? Now a major motion picture starring Tom Cruise!

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Epub⋙: Step-By-Step Basic Statistics Using SAS: Student Guide and Exercises by Larry Hatcher

Step-By-Step Basic Statistics Using SAS: Student Guide and Exercises by Larry Hatcher

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The logical, easy-to-understand approach of this book set makes it indispensible to students in the behavioral and social sciences. The Student Guide first introduces you to SAS software, then leads you through a variety of elementary statistical analyses that are commonly used in the social and behavioral sciences. Even if you are new to statistics and computers, you soon will be recording research data, writing SAS programs, and interpreting the results. Exercises in the companion text enable you to apply what you learned in the Student Guide. Using the instruction provided, you soon will be creating data sets and performing statistical analyses to investigate specific research questions. The exercise data is inspired by studies in the social and behavioral sciences, so your analyses and findings mirror real research.

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Epub⋙: Iceberg Slim: The Life as Art by Peter A. Muckley

Iceberg Slim: The Life as Art by Peter A. Muckley

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The life of Robert Beck is one of tragedy, drama, triumph, and triumphant disappointment. His life and the lives he witnessed inspired the memorable characters he created in his novels and essays penned until his death in 1992.

In Iceberg Slim, unofficial biographer Peter Muckley has dissected the characters and prose of Pimp, Trick Baby, The Naked Soul of Iceberg Slim, Mama Black Widow, Long White Con, Death Wish, Doom Fox, and Airtight Willie and Me to reveal some insightful interpretations as to the significance of these works. Through this exhaustive critique, Muckley has provided an intimate look at the man that the world has come to know as Iceberg Slim.

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Epub⋙: The Time of the Black Jaguar: An Offering of Indigenous Wisdom for the Continuity of Life on Earth (Volume 1) by Arkan Lushwala

The Time of the Black Jaguar: An Offering of Indigenous Wisdom for the Continuity of Life on Earth (Volume 1) by Arkan Lushwala

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The Time of the Black Jaguar speaks to the times of change that we are now living in. The insights contained in the book originate from ancient indigenous cultures. According to what the author learned from his elders, human beings always have a choice between the path of competition and the path of cooperation. The healing of the earth depends on the healing of humanity and will only become possible as we return to a relationship of cooperation with all of life. In order to do this we first need to return to ourselves, remembering our original, inherent wisdom. Indigenous people believe that we humans have all the necessary talents to be caretakers of Mother Earth. This book reveals our true capacities in a strong and clear way, offering the reader not only information, but a real opportunity to participate in the work that needs to be done to save our planet.

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Derick Heinz:

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Epub⋙: Implantable Neuroprostheses for Restoring Function (Woodhead Publishing Series in Biomaterials)

Implantable Neuroprostheses for Restoring Function (Woodhead Publishing Series in Biomaterials)

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Research and developments in neuroprostheses are providing scientists with the potential to greatly improve the lives of individuals who have lost some function. Neuroprostheses can help restore or substitute motor and sensory functions which may have been damaged as a result of injury or disease. However, these minute implantable sensors also provide scientists with challenges. This important new book provides readers with a comprehensive review of neuroprostheses. Chapters in part one are concerned with the fundamentals of these devices. Part two looks at neuroprostheses for restoring sensory function whilst part three addresses neuroprostheses for restoring motor function. The final set of chapters discusses significant considerations concerning these sensors.

• Systematic and comprehensive coverage of neuroprostheses
• Covers the fundamentals of neuroprostheses, their application in restoring sensory and motor function and an analysis of the future trends
• Keen focus on industry needs in the field of biomaterials

From reader reviews:

James Mendoza:

People live in this new time of lifestyle always try to and must have the time or they will get large amount of stress from both lifestyle and work. So , if we ask do people have extra time, we will say absolutely of course. People is human not really a robot. Then we consult again, what kind of activity do you possess when the spare time coming to an individual of course your answer can unlimited right. Then ever try this one, reading publications. It can be your alternative in spending your spare time, the book you have read is definitely Implantable Neuroprostheses for Restoring Function (Woodhead Publishing Series in Biomaterials).

Gayle Anderson:

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Marylouise Potter:

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Epub⋙: Medea and Other Plays: Hecabe, Electra, Heracles by Philip Euripides; Vellacott

Medea and Other Plays: Hecabe, Electra, Heracles by Philip Euripides; Vellacott

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From reader reviews:

Alberta Sanchez:

Have you spare time for just a day? What do you do when you have a lot more or little spare time? Sure, you can choose the suitable activity regarding spend your time. Any person spent their own spare time to take a stroll, shopping, or went to the actual Mall. How about open as well as read a book called Medea and Other Plays: Hecabe, Electra, Heracles? Maybe it is to get best activity for you. You understand beside you can spend your time together with your favorite's book, you can wiser than before. Do you agree with it has the opinion or you have additional opinion?

John Collins:

Your reading 6th sense will not betray you, why because this Medea and Other Plays: Hecabe, Electra, Heracles e-book written by well-known writer whose to say well how to make book which might be understand by anyone who also read the book. Written in good manner for you, leaking every ideas and writing skill only for eliminate your current hunger then you still uncertainty Medea and Other Plays: Hecabe, Electra, Heracles as good book not only by the cover but also by content. This is one book that can break don't determine book by its include, so do you still needing yet another sixth sense to pick this!? Oh come on your looking at sixth sense already said so why you have to listening to a different sixth sense.

Marie Miles:

Many people spending their time period by playing outside along with friends, fun activity along with family or just watching TV the whole day. You can have new activity to spend your whole day by reading a book. Ugh, ya think reading a book can actually hard because you have to take the book everywhere? It ok you can have the e-book, taking everywhere you want in your Smart phone. Like Medea and Other Plays: Hecabe, Electra, Heracles which is getting the e-book version. So , why not try out this book? Let's notice.

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Epub⋙: Technical Analysis for the Trading Professional, Second Edition: Strategies and Techniques for Today's Turbulent Global Financial Markets by Constance M. Brown

Technical Analysis for the Trading Professional, Second Edition: Strategies and Techniques for Today's Turbulent Global Financial Markets by Constance M. Brown

Technical Analysis for the Trading Professional, Second Edition: Strategies and Techniques for Today's Turbulent Global Financial Markets by Constance M. Brown PDF, ePub eBook D0wnl0ad

From reader reviews:

Bill Flores:

Why don't make it to be your habit? Right now, try to ready your time to do the important take action, like looking for your favorite book and reading a guide. Beside you can solve your trouble; you can add your knowledge by the book entitled Technical Analysis for the Trading Professional, Second Edition: Strategies and Techniques for Today's Turbulent Global Financial Markets. Try to the actual book Technical Analysis for the Trading Professional, Second Edition: Strategies and Techniques for Today's Turbulent Global Financial Markets as your pal. It means that it can for being your friend when you really feel alone and beside those of course make you smarter than ever before. Yeah, it is very fortuned for you personally. The book makes you much more confidence because you can know everything by the book. So , let us make new experience and knowledge with this book.

Thelma Martin:

This Technical Analysis for the Trading Professional, Second Edition: Strategies and Techniques for Today's Turbulent Global Financial Markets is great publication for you because the content that is certainly full of information for you who have always deal with world and still have to make decision every minute. That book reveal it details accurately using great plan word or we can say no rambling sentences in it. So if you are read the item hurriedly you can have whole data in it. Doesn't mean it only gives you straight forward sentences but hard core information with attractive delivering sentences. Having Technical Analysis for the Trading Professional, Second Edition: Strategies and Techniques for Today's Turbulent Global Financial Markets in your hand like obtaining the world in your arm, details in it is not ridiculous one particular. We can say that no book that offer you world in ten or fifteen second right but this e-book already do that. So , this is certainly good reading book. Heya Mr. and Mrs. hectic do you still doubt in which?

Jerry Montgomery:

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Epub⋙: Pleasure House (The Pleasure House Tales) (Volume 1) by Scarlet Darkwood

Pleasure House (The Pleasure House Tales) (Volume 1) by Scarlet Darkwood

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Asylums are for the insane, a place where outcasts live and die, where rule-breakers are broken. Strange inhabitants live in secrecy behind locked doors. Lips never speak of what's seen or heard. Unlike the others, The House has one secret it shares with special occupants. Those admitted for transgressions of the flesh are embraced, their curiosity welcomed, their behaviors rewarded. Roles of domination and submission are taught with equal vigor, and those who leave emerge whole and stronger than ever. Rose discovers this truth when she's sent to The House for the treatment of her erotomania. In a time where modesty and prudence are revered, the experience shatters tradition, leaving her with forbidden knowledge few women possess. When she finds herself in the arms of a formidable lover, the gauntlet is thrown, and power unleashes power. **Warning: This story contains scenes that may not be suitable for those with more sensitive tastes. Scenes are filled with unique situations not normally presented in novels of this kind.**

From reader reviews:

Patricia Watts:

Often the book Pleasure House (The Pleasure House Tales) (Volume 1) has a lot info on it. So when you read this book you can get a lot of profit. The book was compiled by the very famous author. Mcdougal makes some research before write this book. This particular book very easy to read you may get the point easily after perusing this book.

Kerry Erdman:

Does one one of the book lovers? If yes, do you ever feeling doubt while you are in the book store? Make an effort to pick one book that you find out the inside because don't assess book by its protect may doesn't work the following is difficult job because you are frightened that the inside maybe not because fantastic as in the outside look likes. Maybe you answer could be Pleasure House (The Pleasure House Tales) (Volume 1) why because the excellent cover that make you consider with regards to the content will not disappoint you actually. The inside or content is definitely fantastic as the outside or even cover. Your reading sixth sense will directly direct you to pick up this book.

David Blunt:

As a student exactly feel bored in order to reading. If their teacher requested them to go to the library or make summary for some reserve, they are complained. Just small students that has reading's soul or real their hobby. They just do what the educator want, like asked to go to the library. They go to generally there but nothing reading critically. Any students feel that examining is not important, boring and can't see colorful photos on there. Yeah, it is for being complicated. Book is very important in your case. As we know that on this era, many ways to get whatever you want. Likewise word says, many ways to reach Chinese's country. So , this Pleasure House (The Pleasure House Tales) (Volume 1) can make you truly feel more interested to read.

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Epub⋙: Deathtrap (Broslin Creek series Book 3) by Dana Marton

Deathtrap (Broslin Creek series Book 3) by Dana Marton

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"As I read, I kept thinking what a good movie this book would make...at the very least, a great episode of Castle!" (TigModeon)

"Dana Marton ranks right up there with some of my favorite authors...Alex Kava, Tess Gerritsen, etc. " (Macti)

Sophie Curtis is a heart-transplant recipient with some spooky body memories. She's been in her own antiseptic bubble for so long, she just might not be able to venture out into the real world again.

Whatever shred of optimism Ethan Bing had left after becoming Broslin Chief of Police had been seared out of him by the unsolved murder of his wife two years ago. Then Sophie pops into his life, and she gets through his defenses like no other, but soon it becomes clear that she's been selected as the killer's next victim.

"Dana has won herself a prize for another great book. I don't know where her ideas come from but she is wonderful about making them come alive. Her characters make you want to invite them to dinner." Margaret Sholders, reviewer

"Until I read Sophie's story, I didn't realize how warrior-strong a heart transplant patient would have to be. She is my new hero. And she deserves her own hero, Broslin Police Chief Ethan Bing, who is up to his mocha-colored eyes in small town crime and two big-time murders." Rich, complex story, with strong mysteries, appealing characters, and a wonderful dog..." Diane Flindt, bookseller

[Although, this book is part of a series, it can be read as a standalone novel.]

From reader reviews:

Trisha Sherman:

As people who live in the actual modest era should be revise about what going on or info even knowledge to make them keep up with the era which can be always change and progress. Some of you maybe may update themselves by reading through books. It is a good choice for yourself but the problems coming to you is you don't know what type you should start with. This Deathtrap (Broslin Creek series Book 3) is our recommendation so you keep up with the world. Why, because book serves what you want and want in this era.

Jennifer Yost:

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Stephanie Landa:

As we know that book is significant thing to add our understanding for everything. By a e-book we can know everything we really wish for. A book is a group of written, printed, illustrated or perhaps blank sheet. Every year had been exactly added. This reserve Deathtrap (Broslin Creek series Book 3) was filled in relation to science. Spend your time to add your knowledge about your science competence. Some people has different feel when they reading some sort of book. If you know how big benefit from a book, you can truly feel enjoy to read a reserve. In the modern era like currently, many ways to get book which you wanted.

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